Rakel RE. Despair. Prim Care. 1999;26:211–24.
Aaronson ST, Sears P, Ruvuna F, Bunker M, Conway CR, Dougherty DD. et al. A 5-year observational examine of sufferers with treatment-resistant despair handled with vagus nerve stimulation or therapy as traditional: Comparability of response, remission, and suicidality. Am J Psychiatry. 2017;174:640–8.
Friedrich MJ. Despair is the main explanation for incapacity world wide. JAMA. 2017;317:1517.
Lynch CJ, Gunning FM, Liston C. Causes and penalties of diagnostic heterogeneity in despair: Paths to discovering novel organic despair subtypes. Biol Psychiatry. 2020;88:83–94.
Sharma V, Doobay M, Baczynski C. Bipolar postpartum despair: An replace and suggestions. J Have an effect on Disord. 2017;219:105–11.
Energy RA, Keers R, Ng MY, Butler AW, Uher R, Cohen-Woods S, et al. Dissecting the genetic heterogeneity of despair via age at onset. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:859–68.
Wickramaratne PJ, Weissman MM. Onset of psychopathology in offspring by developmental section and parental despair. J Am Acad Youngster Adolesc Psychiatry. 1998;37:933–42.
Lyons MJ, Eisen SA, Goldberg J, True W, Lin N, Meyer JM, et al. A registry-based twin examine of despair in males. Arch Gen Psychiatry. 1998;55:468–72.
Cheng YC, Liu SI, Chen CH, Liu HC, Lu ML, Chang CJ, et al. Comparability of cognitive operate between early- and late-onset late-life despair in remission. Psychiatry Res. 2020;290:113051.
Kendler KS, Fiske A, Gardner CO, Gatz M. Delineation of two genetic pathways to main despair. Biol Psychiatry. 2009;65:808–11.
Wilkinson P, Ruane C, Tempest Ok. Despair in older adults. BMJ. 2018;363:k4922.
Gee DG, Casey BJ. The influence of developmental timing for stress and restoration. Neurobiol Stress. 2015;1:184–94.
Saleh A, Potter GG, McQuoid DR, Boyd B, Turner R, MacFall JR, et al. Results of formative years stress on despair, cognitive efficiency and mind morphology. Psychol Med. 2017;47:171–81.
McEwen BS. Formative years influences on life-long patterns of habits and well being. Ment Retard Dev Disabil Res Rev. 2003;9:149–54.
Ruiz R, Roque A, Pineda E, Licona-Limon P, Jose Valdez-Alarcon J, Lajud N. Formative years stress accelerates age-induced results on neurogenesis, despair, and metabolic threat. Psychoneuroendocrinology. 2018;96:203–11.
Culver DA, Newman LS, Kavuru MS. Gene-environment interactions in sarcoidosis: Problem and alternative. Clin Dermatol. 2007;25:267–75.
Heim C, Binder EB. Present analysis traits in formative years stress and despair: Evaluate of human research on delicate durations, gene-environment interactions, and epigenetics. Exp Neurol. 2012;233:102–11.
Wang Q, Shelton RC, Dwivedi Y. Interplay between early-life stress and FKBP5 gene variants in main depressive dysfunction and post-traumatic stress dysfunction: A scientific assessment and meta-analysis. J Have an effect on Disord. 2018;225:422–8.
Shenassa ED, Rogers ML, Buka SL. Maternal smoking throughout being pregnant, offspring smoking, opposed childhood occasions, and threat of main despair: A sibling design examine. Psychol Med. 2021:1–11. https://doi.org/10.1017/S0033291721001392.
Balfour DJ, Ridley DL. The consequences of nicotine on neural pathways implicated in despair: A think about nicotine habit? Pharm Biochem Behav. 2000;66:79–85.
Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: An open entry useful resource for figuring out the causes of a variety of advanced illnesses of center and outdated age. PLoS Med. 2015;12:e1001779.
Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, et al. Minimal phenotyping yields genome-wide affiliation indicators of low specificity for main despair. Nat Genet. 2020;52:437–47.
Dudbridge F. Polygenic epidemiology. Genet Epidemiol. 2016;40:268–72.
Jirtle RL, Skinner MK. Environmental epigenomics and illness susceptibility. Nat Rev Genet. 2007;8:253–62.
Gluckman PD, Hanson MA, Beedle AS. Formative years occasions and their penalties for later illness: A life historical past and evolutionary perspective. Am J Hum Biol. 2007;19:1–19.
Safi-Stibler S, Gabory A. Epigenetics and the developmental origins of well being and illness: Parental atmosphere signalling to the epigenome, important time home windows and sculpting the grownup phenotype. Semin Cell Dev Biol. 2020;97:172–80.
Barboza Solis C, Kelly-Irving M, Fantin R, Darnaudery M, Torrisani J, Lang T, et al. Hostile childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British beginning cohort. Proc Natl Acad Sci USA. 2015;112:E738–746.
Wilkowska-Chmielewska J, Szelenberger W, Wojnar M. Age-dependent symptomatology of despair in hospitalized sufferers and its implications for DSM-5. J Have an effect on Disord. 2013;150:142–5.
Nguyen TD, More durable A, Xiong Y, Kowalec Ok, Hagg S, Cai N, et al. Genetic heterogeneity and subtypes of main despair. Mol Psychiatry. 2022;27:1667–75.
Coffey JK, Xia M, Fosco GM. When do adolescents really feel liked? A day by day within-person examine of parent-adolescent relations. Emotion. 2020. https://doi.org/10.1037/emo0000767.
Norman RE, Byambaa M, De R, Butchart A, Scott J, Vos T. The long-term well being penalties of kid bodily abuse, emotional abuse, and neglect: A scientific assessment and meta-analysis. PLoS Med. 2012;9:e1001349.
Mandelli L, Petrelli C, Serretti A. The position of particular early trauma in grownup despair: A meta-analysis of revealed literature. Childhood trauma and grownup despair. Eur Psychiatry. 2015;30:665–80.
Heim C, Shugart M, Craighead WE, Nemeroff CB. Neurobiological and psychiatric penalties of kid abuse and neglect. Dev Psychobiol. 2010;52:671–90.
Nemeroff CB. Paradise misplaced: The neurobiological and medical penalties of kid abuse and neglect. Neuron. 2016;89:892–909.
Floudas CS, Um N, Kamboh MI, Barmada MM, Visweswaran S. Figuring out genetic interactions related to late-onset Alzheimer’s illness. BioData Min. 2014;7:35.
Chan YE, Chen MH, Tsai SJ, Bai YM, Tsai CF, Cheng CM, et al. Therapy-Resistant despair enhances dangers of dementia and Alzheimer’s illness: A nationwide longitudinal examine. J Have an effect on Disord. 2020;274:806–12.
Barnes DE, Yaffe Ok, Byers AL, McCormick M, Schaefer C, Whitmer RA. Midlife vs late-life depressive signs and threat of dementia: differential results for Alzheimer illness and vascular dementia. Arch Gen Psychiatry. 2012;69:493–8.
Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, et al. GSAP regulates lipid homeostasis and mitochondrial operate related to Alzheimer’s illness. J Exp Med. 2021;218:e20202446.
Yun HM, Park KR, Kim EC, Kim S, Hong JT. Serotonin 6 receptor controls Alzheimer’s illness and despair. Oncotarget. 2015;6:26716–28.
Ciaccio C, Leonardi E, Polli R, Murgia A, D’Arrigo S, Granocchio E, et al. A missense de novo variant within the CASK-interactor KIRREL3 gene resulting in neurodevelopmental dysfunction with gentle cerebellar hypoplasia. Neuropediatrics. 2021;52:484–8.
Hisaoka T, Komori T, Kitamura T, Morikawa Y. Irregular behaviours related to neurodevelopmental problems in Kirrel3-knockout mice. Sci Rep. 2018;8:1408.
Roh JD, Choi SY, Cho YS, Choi TY, Park JS, Cutforth T, et al. Elevated excitatory synaptic transmission of dentate granule neurons in mice missing PSD-95-interacting adhesion molecule Neph2/Kirrel3 in the course of the early postnatal interval. Entrance Mol Neurosci. 2017;10:81.
Peric I, Stanisavljevic A, Inta D, Gass P, Lang UE, Borgwardt S, et al. Tianeptine antagonizes the discount of PV+ and GAD67 cells quantity in dorsal hippocampus of socially remoted rats. Prog Neuropsychopharmacol Biol Psychiatry. 2019;89:386–99.
Wang Q, He Ok, Li Z, Chen J, Li W, Wen Z, et al. The CMYA5 gene confers threat for each schizophrenia and main depressive dysfunction within the Han Chinese language inhabitants. World J Biol Psychiatry. 2014;15:553–60.
Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, et al. Frequent variation within the miR-659 binding-site of GRN is a serious threat issue for TDP43-positive frontotemporal dementia. Hum Mol Genet. 2008;17:3631–42.
Hsiung A, Naya FJ, Chen X, Shiang R. A schizophrenia related CMYA5 allele shows differential binding with desmin. J Psychiatr Res. 2019;111:8–15.
Takkinen S, Gold C, Pedersen NL, Malmberg B, Nilsson S, Rovine M. Gender variations in despair: a examine of older unlike-sex twins. Getting old Ment Well being. 2004;8:187–95.
Chung MC, Chen ZS. Gender variations in little one abuse, emotional processing difficulties, alexithymia, psychological signs, and behavioural issues amongst Chinese language adolescents. Psychiatr Q. 2020;91:321–32.
de Lima RMS, Dos Santos Bento LV, di Marcello Valladao Lugon M, Barauna VG, Bittencourt AS, Dalmaz C, et al. Formative years stress and the programming of consuming habits and anxiousness: Intercourse-specific relationships with serotonergic exercise and hypothalamic neuropeptides. Behav Mind Res. 2020;379:112399.
