• Home
  • Mental Health
  • Depression
  • Meditation
  • Stress Disorders
  • Anxiety
  • Mental Illness
  • Contact Us
No Result
View All Result
Natural Element
  • Home
  • Mental Health
  • Depression
  • Meditation
  • Stress Disorders
  • Anxiety
  • Mental Illness
  • Contact Us
No Result
View All Result
Natural Element
No Result
View All Result

Can Oversensitive Sensory Neurons Cause Joint Deformities

January 20, 2023


An excessive amount of mechanosensation in the neurons that sense one’s limbs in space can cause musculoskeletal deformities such as arthrogryposis.

Their study also provides proof of concept that reducing this heightened sensory neuronal activity (via Botox or special diet) during a critical age could be a viable way to treat some musculoskeletal conditions in a non-invasive manner.

What is Distal Arthrogryposis

Distal arthrogryposis (DA) is a disorder characterized by congenital joint deformities, or contractures, that often restrict movement in the hands and feet and is estimated to afflict roughly one in 3,000 individuals worldwide. Alleviating the symptoms often requires invasive surgeries.

Although mutations in genes associated with muscle and joint function have been linked to DA, gain-of-function mutations in PIEZO2 – a principal mechano-sensor in sensory neurons that underlies touch sensation, proprioception, and other mechanosensory processes – have been found in patients with DA subtype 5 (DA5). However, the mechanism by which PIEZO2 mutations cause DA is unknown.

Using a mouse model, Shang Ma and colleagues found that over-expression of the mutant PIEZO2 gain-of-function allele in proprioceptive neurons that enervate muscles and tendons during a critical postnatal period during development can cause joint contracture. These defects were not caused when the dysfunctional allele was expressed in skeletal muscles, cartilage, or tendons.

Advertisement


“Finding that expression of the gain-of-function allele of PIEZO2 in young adult mice does not cause DA symptoms is reassuring. It narrows down a time window for potential therapeutic intervention that could lead to lifelong improvement for the affected patients,” said Ma et al.

Source: Eurekalert



Source_link

Share120Tweet75Share30

Related Posts

Back-to-school blues are normal, so how can you tell if it’s something more serious?
Anxiety

Back-to-school blues are normal, so how can you tell if it’s something more serious?

February 1, 2023

Many children come down with a case of the back-to-school blues as summer slips away. Having spent the holidays staying up late and having fun with friends and family, it can be a struggle to get back into a...

Does Vaping E-cigarettes Cause Lung Damage
Anxiety

Does Vaping E-cigarettes Cause Lung Damage

February 1, 2023

Investigators found that even low exposure to aerosols from JUUL—a brand of e-cigarettes popular with youth and young adults—had significant impacts. "The health consequences of vaping are not known. Our results show that inhalation of the vapor generated by...

Can chewing help manage stress, pain and appetite? Here’s what the science says
Anxiety

Can chewing help manage stress, pain and appetite? Here’s what the science says

January 31, 2023

Ever feel a bit stressed or need a concentration boost? Research suggests one remedy may be right under your nose. Chewing has benefits for brain function, stress, anxiety, exam performance, pain perception, as well as hunger and food intake....

Is Artificial Skin More Sensitive Than Natural Skin
Anxiety

Is Artificial Skin More Sensitive Than Natural Skin

January 31, 2023

, scientists used the dual-responsive artificial skin for a variety of applications, including manipulation of virtual game characters, navigation of electronic maps, and scrolling through electronic documents. Distinct signals could be detected by the artificial skin upon different approaching...

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Categories

  • Anxiety (441)
  • Depression (136)
  • Meditation (210)
  • Mental Health (428)
  • Mental Illness (383)
  • Sound Therapy (2)
  • Stress Disorders (245)

Popular

  • Stress Level Of Americans Is Rising Rapidly In 2022, New Study Finds

    Stress Level Of Americans Is Rising Rapidly In 2022, New Study Finds

    302 shares
    Share 121 Tweet 76
  • 4 signs of burnout in your teen– and how to help them through it

    302 shares
    Share 121 Tweet 76
  • How Stress Affects Your Vision

    302 shares
    Share 121 Tweet 76
  • Helpful Resources During Suicide Prevention Month 2022 – My Brain’s Not Broken

    301 shares
    Share 120 Tweet 75
  • The Covid Symptoms No One is Talking About, But You Need to Know, Say Experts — Eat This Not That

    301 shares
    Share 120 Tweet 75

  • Home
  • About Us
  • Contact Us
  • Disclaimer
  • Privacy Policy
  • Terms & Conditions

Copyright © 2022 Naturalele.com | All Rights Reserved.

No Result
View All Result
  • Home
  • Mental Health
  • Depression
  • Meditation
  • Stress Disorders
  • Anxiety
  • Mental Illness
  • Contact Us
What Are Cookies
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Cookie Settings" to provide a controlled consent.
Cookie SettingsAccept All
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT